Until about 1980, taxonomists placed a number of species, including this one, under Phyllanthus niruri L. Where the name Phyllanthus niruri has been applied in older literature to African or Asian specimens, usually Phyllanthus amarus is intended, but sometimes also Phyllanthus debilis, Phyllanthus fraternus, Phyllanthus maderaspatensis or Phyllanthus rotundifolius. An equally important action is the use against kidney stones (renal calculi), urinary tract- and bladder infections. A systematic study about its toxic effects when chronically and excessively administered is still lacking. Phyllanthus (Chanca piedra) is used extensively in Chinese - and Ayurvedic medicine throughout the centuries for liver, kidney and gall bladder function. Tovar J, Bjorck IM, Asp N-G. Animals and ethical concerns: This study is part of a project on the histological effects of P amarus research. The solutions were . The present study was undertaken to investigate the protective effect and possible mechanism of aqueous extract from Phyllanthus amarus Schum. All parts of this small plant have many medicinal applications and are used as such. Photomicrographs were obtained using research photographic microscope in the Department of Anatomy, School of Basic Medical Sciences, University of Benin, Benin city, Edo State, Nigeria. Phytochemically, P. amarus contains alkaloids, antioxidants (including flavonoids, phenols and polyphenols) and lignans5. Contraceptive effects of Phyllanthus amarus in female mice. The 75 mg/kg PA dose gave the best result similar to SL. Aqueous extract of Phyllanthus amarus (P. amarus) treatment exhibited potent anticarcinogenic activity against 20-methylcholanthrene (20-MC) induced sarcoma development and increased the survival . * Previously called Phyllanthus Complex (name change only). Universidad Nacional de Rosario. The animal care and use ethics was in compliance to the Animal Holdings protocol overseen by the head of department through the Animal Holding unit. Combination of ethanolic extract of Phyllanthus amarus and silymarin gives synergistic hepatoprotective activity against carbon tetrachloride-induced hepatotoxicity. Comment of the reviewer Daniel Al Kassam PhD. These are the pictures of Phyllanthus amarus; this plant has broad leaves arranged in opposite directions along the mid-rib of the plant. Medicinal Plantlist | Medicinal Seedlist | Rhizomes and bulbs | Spices | Son necesarios estudios para identificar el o los agentes causales. El grupo A recibi� P. amarus en dosis �nica de 400 mg/kg de peso corporal al d�a durante treinta d�as mediante sonda g�strico, el grupo B recibi� P. amarus en una sola dosis de 800mg/kg de peso corporal al d�a con el mismo procedimiento y per�odo, y el grupo C fue de ratas control, que recibi� el mismo volumen de agua destilada en id�nticas condiciones que A y B. Las ratas fueron alimentadas con pienso especial para ratas y agua ad libitum. Tropical Cut Flowers | Tropical fruit seeds | The Phyllanthus amarus plant suppresses HBV mRNA transcription in vitro and exhibits therapeutic potential in chronic HBV carriers, although further work is necessary to define its mechanism of action. Sus resultados, si bien no son directamente extrapolables al ser humano y se han obtenido mediante t�cnicas histol�gicas corrientes, no resultan descartables pues sirven, por un lado, para advertir indiciariamente sobre los riesgos del uso cr�nico, indiscriminado y nada sistem�tico del P. amarus (de similares efectos a la pimienta roja en el est�mago), y, por otra parte, para alentar profundizaciones investigativas sobre este menester. The dose of 2, 4, 6 and 8gm/kg . ties, petroleum ether extract, Phyllanthus debilis Introduction Phyllanthus amarus Schum and Thonn (Euphorbiaceae) and Phyllanthus debilis Klein. Due to the poor water solubility of its major constituents such as lignans and flavonoids, its absorption upon oral administration could be limited. Palabras clave: Toxicidad antioxidante. In vitro gel shifts showed that P. amarus inhibited complexing of C/EBP transcription factors to a consensus oligonucleotide sequence, whereas DNA binding of AP-1 and SP-1 transcription factors was unaffected. J Biosci 2005;30:245-52. Potential toxicity of flavonoids and other dietary phenolics: significance for their chemopreventive and anticancer properties. Aim: The aim of the present study was to investigate the effects of the administration of P. amarus on garlic-induced hepatotoxicity in rats. Faremi TY, Suru SM, Fafunso MA, Obioha UE. What is the benefit of Stone Breaker? Hepatoprotective Potential of Endophytic Aspergillus Niger Strain A6 Fractions Isolated from Phyllanthus Amarus Schum and Thonn, Aim: To isolate, characterize and screen for the in vitro antioxidant and hepatoprotective effects of P1EA and P1nB extracts from the endophytic fungi Aspergillus niger strain A6 (PALF-1) isolated from leaves of Phyllanthus amarus in paracetamol induced hepatotoxicity. Facultad de Ciencias M�dicas. Sections were discretionally selected from groups [B] and [C] only for comparison. Bhumi Amla (Phyllanthus niruri) is a tropical weed which grows extensively in the coastal areas. Glick Z, Joslyn MA. et Thonn. The ethanol extract of Phyllanthus amarus (Schum and Thonn), a plant of ethnomedicinal importance, was formulated into herbal cream and ointment and evaluated using physicochemical, safety and antimicrobial properties. The toxic effects of P. amarus has been suggested in literature12-13. Uses, Benefits, Cures, Side Effects, Nutrients in Phyllanthus Amarus. Histological studies of the effects of oral administration of aqueous extract of Phyllanthus amarus commonly used in ethno medical practice in Africa for the management of various ailments such as kidney stones, dysentery, jaundice, diarrhoea and urogenital diseases on the kidney of adult Wistar rats were carefully studied. The duodenum treated with P amarus showed signs of erosion and inflammation, which are suggestive of ulcerations. The book guides you to adopt a healthy lifestyle based on the ancient Indian Medical Science - Ayurveda. Read further for details. Revised and updated for the second edition, this reference volume draws on biosynthetic relationships to describe both the primary and secondary classes of matabolites and the drugs from which they originate. Hepatoprotective effect of ethanolic extract of Phyllanthus amarus Schum. Phyllanthus amarus (P. amarus) is commonly used for traditional Indian medicine and as dietary adjuncts for the treatment of numerous physiological disorders including hepatic disorders. Rats of both sexes (n=24), average weight of 260g were randomly . Facultad de Ciencias M�dicas. Phyllanthus niruri has extensive medicinal properties and has long history in the health care system of tropical countries. Nature has always been, and still is, a source of food and ingredients that are beneficial to human health. Bhumi Amla juice benefits as a treatment of jaundice. Found inside – Page 379Phyllantus niruri (phyllanthus) (euphorbiaceae) antitumor Cytotoxic Location: Northern Asia Appearance: Stem: 0.5 m high, ... Indicative dosage and application: against the growth of the murine P-388 lymphocytic leukemia cell line in a ... Rats were euthanized by cervical dislocation on the thirty-one day of the experiment and the stomach and the duodenum were immediately dissected out and fixed in 10% formaldehyde- saline for routine histological techniques. Kendabie KO, Adjene JO. Summing up, it calls for caution and discretion as occurs with other medicines. € 6.55. for the concomitant treatment of liver diseases. DOSAGE OF PHYLLANTUS AMARUS FOR HEPATITIS B INFECTION : Half or one full cup to be taking 2 times daily on empty stomach for 30 days consistently. Detox | Garden plants | Found inside – Page 8-1Formula Nine: A. Phyllanthus amarus leaves and stems B. Elaeis guineensis palm kernel oil C. Aframomum melegueta The plant material is boiled in water, to make a soup. Dosage: drink the soup daily. Formula Ten: A. Cajanus cajan leaves ... Last but nor the least, we hypothesize the P amarus may be contraindicated in stomach ulcer patients. This book will be a valuable resource for researchers, students, diagnosticians, veterinarians, fish pathologists and microbiologists concerned with the management of diseases of fish and shellfish. The animals were fed with grower's mash obtained from Edo Feeds and Flour Mill Limited, Ewu, Edo State, Nigeria and received water ad libitum. Phyllanthus varieties are commonly used in Ayurveda—particularly Phyllanthus niruri.In addition, Phyllanthus amarus is an Amazonian variety that is used in South America.This article will specifically focus on Phyllanthus niruri health benefits. Fresh Phyllanthus is generally considered a weed and can be foraged from nature, although a horticulturist may be needed to identify the species. Received September 09, 2010. The present study was carried out to investigate the effects of 80% ethanolic extract . It is a common weed, which grows well in moist, shady and sunny places. The leaves were cleaned, oven-dried at 50°C and macerated into dry powder. Universidad Nacional de Rosario. Your digestive system and how it works. The increased level of serum alkaline phosphatase is reliable marker of liver damage, which occurs due to the de novo synthesis by the liver cells (Muriel and Escobar, 2003). Materials and Methods: Experimental rats were divided into two groups: Control and Phyllanthus amarus (P. amarus) treated. "A clinically-oriented, scientifically-based guide to the use of diet, nutritional supplements, and other natural substances for the prevention and treatment of a wide range of physical and mental disorders..." -- To study the effect of P. amarus on a leukocyte migration assay, neutrophils were purified from the blood of rats that were pretreated with or without the 80% ethanol extract of P. amarus. The muscularis mucosa of the stomach was well noticed in the control section (Fig.1a). demuestran que Phyllanthus amarus produce da�o en ratas. Phyllanthus niruri is a plant with medicinal properties. 1b). The popularity of herbal remedies is increasing and many patients with liver disease use them. All of these chemical components have their useful as well as toxic effects. By nagendra chauhan. Histological studies of the effects of oral administration of aqueous extract of Phyllanthus amarus commonly used in ethno medical practice in Africa for the management of various ailments such as kidney stones, dysentery, jaundice, diarrhoea and urogenital diseases on the kidney of adult Wistar rats were carefully studied. For the right freight rate, please visit our Indian J Exp Biol 2008;46:514-20. Results: Rats in the treated groups showed some distortions in the epithelial cells of the stomach and the duodenum and signs of inflammation, when compared with controls. Phyllanthus amarus: Ethnomedicinal uses, phytochemistry and pharmacology: A review. SWPS 590 Smollett Street. Aloe Vera and peppermint also helps to relieves that nagging and distressing muscles pains called sciatica. Adem�s, seria de utilidad valorar a partir de que dosis de cada compuesto aparece el da�o. The study was carried out to determine if the aqueous leaf extract of P. niruri administered to female Sprague-Dawley rats would illicit evidence of toxicity. 11. A combination of three traditional herbal extracts that support the liver: milk thistle seed, Phyllanthus amarus leaf, and dandelion root. This important book comprises a narrative account of research on the hepatitis B virus (and related subjects) and selected reprints from the laboratory of Nobel laureate Baruch S Blumberg and his colleagues.   This book highlights the medical importance of and increasing global interest in herbal medicines, herbal health products, herbal pharmaceuticals, nutraceuticals, food supplements, herbal cosmetics, etc. The results obtained show that the extract has blood pressure lowering effect which may be by the combined effects of myocardial depression, muscarinic receptor mediated vascular smooth muscle relaxation and by the calcium channel ion blockade in vascular smooth Muscle. Therefore, we sought to examine the protective effects of . It is also known that while food is emptied from the mouth and oesophagus as quickly as it is swallowed, emptying of the stomach and small intestine in digestive process is relatively slow and not consciously controlled. The final Materia medica of Sida alnifolia and Phyllanthus amarus have been formed after proving the drug in tincture, 30C and 200C, followed by clinical verification of these proved symptoms. Evaluation of oxidant and antioxidant status in term neonates. However, the effects of PA in modulating immune responses in the central nervous system leading to protection against functional changes remain unexplored. Therefore, the stomach and duodenum are logically the regions of the digestive tract that may be most affected by any toxic component of foods. However, herbal therapies have not been effusively researched or standardized to enable clinical application1. J Nutr 1970;100:509-15. Yercaudhill is situated on the North Eastern part of the state of Tamil Nadu under Salem District. The symptoms included in final Materia medica were selected based on certain criteria, which are given below in the order of importance. The keezhanelli is a flowering plant used in herbal medicine, which grows about 50-70 cm height. Marion Bessin Liver Research Center and Gastroenterology Division, Department of Medicine, Albert Einstein College of Medicine, Bronx, NY, USA, Department of Microbiology, Dr A. L. M. Postgraduate Institute of Basic Medical Sciences, Madras, India. Son necesarios estudios para identificar el o los agentes causales. The School of Basic Medical Sciences, University of Benin granted approval before the work began. In reality, two different species - Phyllanthus niruri and Phyllanthus amarus - are both referred to as chanca piedra or "stone breaker" [2, 3]. The most studied species is Phyllanthus amarus. 14. One of such species which have wide patronage of use is Phyllanthus amarus. Received September 09, 2010. Medicine from Nature | Oils | Only the group B animals have been compared with control group C in this study. fMLP induced neutrophil chemotaxis under the control conditions, and pretreatment of the rats with extract of P. amarus at doses ranging from 100 to 400 mg . It is particularly used traditionally in the treatment of several bowel diseases including diarrhea, dysentery and ulcers5,10-11. When 20 subjects in the Phyllanthus amarus group were given a further 30-day treatment and 22 placebo recipients given Phyllanthus amarus 1,200 mg per day for 30 days, the conversion was observed in 1 (5%) in the higher dose group. Correspondence: Complement Ther Med 2008; 16:81-6. The photomicrograph of the stomach section from the control group showed normal histological features with the mucosa lined with simple columnar epithelial cells, lamina propria with some highly packed glandular secretory cells. The plant is known in traditional health care systems. Phyllanthus amarus (P. amarus) is an ethnobotanical plant that is distributed in almost all tropical countries and regions including America, India and Nigeria. P. niruri is commonly known as "Chanca pedra" (or) "stone breaker". Incomplete digestion of legume starches in rats: a study of precooked flours containing retrograded and physically inaccessible starch fractions. Chanca piedra is an herb. Information is presented on a variety of foods including herbs, fruits, soy and olive oil. This book serves as a valuable resource for researchers in nutrition, nephrology, and gastroenterology. The serum level of Interleukin-6 and Interleukin-8 significantly decreased (p < 0.05) in a dose dependent manner when the extract-treated groups were compared with . Espa�a. Sci Res Essays 2008;3:410-5. Please check your email for instructions on resetting your password. P. amarus also contains alkaloids and lots of other antioxidants5, 9, which has been administered in this study to apparently healthy animals. The effects of the air-drying temperature on the phenolic content and the LC-MS profile were also studied. Tropical plants in the genus Phyllanthus have a long history of use in Ayurvedic medicine (the traditional medicine of India) for the treatment of hepatitis, kidney and bladder problems, intestinal parasites, and diabetes. The deparaffinized sections were stained routinely with haematoxyline and eosin (H&E). Phyllanthus amarus for liver health. Ann Intern Med 2005;142:37-46. Dr Uba Nwose. It is likely that the herb may be contraindicated in gastro-ulcer patients. Evaluation of oxidant and antioxidant status in infants with hyperbilirubinemia and kernicterus. Found inside – Page 565Dosage and Toxicity Pharmacokinetic studies on etoposide showed that this drug is safer even for the above therapeutic doses and is without any hepatotoxic effects (Aita et al., 1999). PHYLLANTHUS AMARUS (CHANCA PIEDRA) ... Harikumar KB, Kuttan R. An extract of Phyllanthus amarus protects mouse chromosomes and intestine from radiation induced damages. Send e- mail | Special Links | This work is part of Josiah Adjene's main research supported by the University of Benin. Animals in group C received equal volume of distilled water, for the same period and through the same route of administration. In phase 2, after a 1-week washout period, the animals were orally admin-istered with 500 mg/kg P. amarus extract once a day (o.d.) Background:Phyllanthus amarus (PA) is widely studied for its hepatoprotective properties but has recently received increasing attention due to its diverse anti-inflammatory effects. Cholesterol & triglyceride Phyllanthus lowers cholesterol & triglyceride levels. These results not only were congruent with a former report related with the toxic effects of red pepper administration on the cytoarchitecture of the stomach18, and with others found in the available literature12-13.

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